Therapeutic effects of combination of Galla rhois extract and Sodium chlorate on Mice infected with Brucella abortus / 동물의과학연구지
Journal of Biomedical Research
;
: 1-6, 2014.
Article
in English
| WPRIM
| ID: wpr-70427
ABSTRACT
This study investigated the therapeutic effects of Galla rhois (GR) ethanol extract (GRE), sodium chlorate (SC), and a combination of GRE and SC on mice infected with Brucella abortus (B. abortus). Mice were infected intraperitoneally with B. abortus and then treated with GRE, SC, and a combination GRE and SC in drinking water for 14 days. Then, serum antibodies were used in a tube agglutination test (TAT), after which the weight and CFUs from each spleen were measured. In addition, histopathological changes in each liver were examined at 14 days post-infection. At 14 days post-infection, negative reactions of serum antibodies in PC (positive control), SCT (SC 1.6 g/L drinking water), GRT (GRE 200 mg/L drinking water), and GST (GRE 200 mg + SC 1.6 g/L drinking water) were 0, 40, 60, and 80%, respectively. The average spleen weight was not significantly different between the groups. At 14 days post-infection, bacterial numbers in all treated groups were significantly lower compared to to that of the PC (GRT and SCT, P<0.05; GST, P<0.001). In terms of histopathological changes in the livers, there were numerous multifocal microgranulomas in the PC, whereas this number successively decreased in the SCT, GRT, and GST groups. Conclusively, a combination of GRE and SC exhibits therapeutic effects on mice infected with B. abortus. These results suggest the potential efficacy of a mixture of GRE and SC in the treatment of brucellosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sodium
/
Spleen
/
Drinking Water
/
Brucella abortus
/
Brucellosis
/
Agglutination Tests
/
Ethanol
/
Drinking
/
Liver
/
Antibodies
Limits:
Animals
Language:
English
Journal:
Journal of Biomedical Research
Year:
2014
Type:
Article
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