Recent progress on crystallizations of amorphous pharmaceutical solids / 中国药科大学学报
Journal of China Pharmaceutical University
;
(6): 654-662, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-704299
ABSTRACT
Compared to their crystalline form,amorphous drugs exhibit higher solubility and faster dissolution rate and thus enhancing oral bioavailability of poorly water soluble drugs.However,since the amorphous form is thermodynamically unstable relative to the crystalline form,amorphous solids tend to crystallize over time and subsequently negate their advantages.This review briefly describes fundamental aspects of amorphous substances and highlights the recent advances of fast crystallization behaviors.Understanding the inherent crystallization mecha nisms of amorphous materials is of utmost importance in order to control the physical stability and lead to efficient formulation development of amorphous pharmaceutical solids.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of China Pharmaceutical University
Year:
2017
Type:
Article
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