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Meta-analysis of Shenling Baizhu Powder Combined with Aminosalicylic Acid Preparation in the Treatment of Ulcerative Colitis / 中国药房
China Pharmacy ; (12): 5119-5122, 2017.
Article in Zh | WPRIM | ID: wpr-704489
Responsible library: WPRO
ABSTRACT
OBJECTIVE:To evaluate clinical efficacy of Shenling baizhu powder combined with aminosalicylic acid in the treatment of ulcerative colitis (UC),and to provide evidence-based reference in clinic.METHODS:Retrieved from PubMed,Cochrane library,CJFD,VIP,Wanfang database and CBM,randomized controlled trials (RCTs) about Shenling baizhu powder combined with aminosalicylic acid preparations (trial group) vs.aminosalicylic acid preparations alone (control group) in the treatment of UC were collected.Meta-analysis was performed by using Rev Man 5.2 statistical software afder data extraction and quality evaluation with Cochrane systematic evaluator manual 5.1.0.RESULTS:A total of 14 RCTs were included,involving 1 177 patients.Meta-analysis showed that total response rate of trial group was significantly higher than that of control group [OR=3.40,95% CI (2.44,4.74),P<0.001],while Sutherland DAI score [MD=-1.31,95% CI (-2.07,-0.56),P<0.001],the levels of TNF-α [SMD=-1.90,95%CI(-2.90,-0.90),P<0.001],IL-17[MD=-85.18,95%CI(-100.51,-69.85),P<0.001] and IL-23 [MD=-113.27,95%CI(-132.34,-94.21),P<0.001] in trial groups were significantly lower than control group,with statistical significance.CONCLUSIONS:Therapeutic efficacy of Shenling baizhu powder combined with aminosalicylic acid preparation is better than aminosalicylic acid preparation alone in the treatment of UC,and can significantly reduce Suthedand DAI and the levels of serum cytokines.
Key words
Full text: 1 Index: WPRIM Type of study: Clinical_trials / Guideline / Systematic_reviews Language: Zh Journal: China Pharmacy Year: 2017 Type: Article
Full text: 1 Index: WPRIM Type of study: Clinical_trials / Guideline / Systematic_reviews Language: Zh Journal: China Pharmacy Year: 2017 Type: Article