Effects of Non-ionic Polyacrylamide Alone or Combined with Nanoscale Silica Gel on the Stability of Glycyrrhetinic Acid Lipo-emulsion / 中国药房
China Pharmacy
;
(12): 1480-1482, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-704826
ABSTRACT
OBJECTIVE:
To investigate the effects of non-ionic polyacrylamide(modelNPAM 1400)alone or combined with nanoscale silica gel (nSiO2) on the stability of Glycyrrhetinic acid lipo-emulsion.METHODS:
UV-spectrophotometer was used to determine absorbance of diluent at 500 nm before and after lipo-emulsion centrifugation. Using the preparation without stable excipient as blank,stability coefficient (KE) and it ratio (KE/KE blank) were calculated. Effects of different concentrations (200-600 mg/L) of non-ionic polyacrylamide on the stability of Glycyrrhetinic acid lipo-emulsion were evaluated. The optimal concentration of non-ionic polyacrylamide alone was determined primarily,and then the effects of it combined with different concentrations of hydrophilic nSiO2 (0.2%, 0.3%, 0.4%) or hydrophobic (0.2%, 0.3%, 0.5%) on the stability of Glycyrrhetinic acid lipo-emulsion were investigated.RESULTS:
When adding non-ionic polyacrylamide alone,KE of Glycyrrhetinic acid lipo-emulsion mixed with 300 mg/L non-ionic polyacrylamide was the lowest,KE/KE blank was 0.22;when combined,KE of Glycyrrhetinic acid lipo-emulsion mixed with 300 mg/L non-ionic polyacrylamide and 0.2% hydrophobic nSiO2 was the lowest,KE/KE blank was 0.27.CONCLUSIONS:
Non-ionic polyacrylamide alone or combined with nSiO2 all can promote the stability of Glycyrrhetinic acid lipo-emulsion,among which 300 mg/L non-ionic polyacrylamide alone is the best.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2018
Type:
Article
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