Risk Factors for Antibiotic-associated Diarrhea in Chinese Adult Patients:A Meta-analysis / 中国药房
China Pharmacy
;
(12): 2845-2850, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-704901
ABSTRACT
OBJECTIVE:
To evaluate the risk factors for antibiotic-associated diarrhea (AAD) in Chinese adult patients systematically,and to provide evidence-based reference in clinic.METHODS:
Retrieved from CNKI,VIP,CBM,Wanfang database,PubMed and Embase,etc.,disease control studies about AAD risk factors of Chinese adult patients were collected.The retrieval time limit ranged from Jan. 2000 to Jan. 2018. Meta-analysis was performed by using Rev Man 5.2 software after data extraction and quality evaluation of included literatures with NOS scale.RESULTS:
A total of 14 literatures were included, involving 20 914 patients. The result of Meta-analysis showed that age ≥65 years [OR=2.36,95%CI(1.99,2.79),P<0.001], fasting [OR=4.65,95%CI(3.79,5.69),P<0.001],use of acid suppressant [OR=5.82,95%CI(3.77,8.98),P<0.001],serum albumin ≤30 g/L [OR=2.40,95%CI(2.00,2.88),P<0.001],invasive operation [OR=3.95,95%CI(3.03,5.15),P<0.001], stay in ICU [OR=2.93,95%CI(2.38,3.60),P<0.001],hospitalization time ≥10 d [OR=4.08,95%CI(3.31,5.03),P<0.001], antibiotic species ≥3 kinds [OR=1.98,95%CI(1.56,2.51),P<0.001] and duration of antibiotics use ≥10 d [OR=6.16,95%CI (3.22,11.76),P<0.001] were significantly correlated with the occurrence of AAD.CONCLUSIONS:
Age ≥65 years,fasting, use of acid suppressant,serum albumin ≤30 g/L,invasive operation,stay in ICU,time of hospitalization ≥10 d,antibiotic species≥3 kinds and duration of antibiotics use≥10 d are risk factors for AAD in Chinese adult patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Risk factors
/
Systematic reviews
Language:
Chinese
Journal:
China Pharmacy
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS