Polymorphisms in GLIS3 Associated with Diabetic Retinopathy in Patients with Type 2 Diabetes in Northeast China / 中国医科大学学报
Journal of China Medical University
;
(12): 909-912, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-704915
ABSTRACT
Objective To investigate the correlation between the polymorphisms in GLIS3 and diabetic retinopathy in patients with type 2 diabetes in Northeast China.Methods Based on the case-control study,polymorphisms in GLIS3 were examined by PCR-RFLP in 120 cases of diabetic retinopathy in patients with type 2 diabetes (DR),120 cases of patients with type 2 diabetes without diabetic retinopathy (DNR),and 120 healthy individuals (NC).The odds ratio (OR) and 95% confidence interval (C I) were calculated using unconditional logistic analysis.Results The resuhs demonstrated that GLIS3 rs7041847 AG,AG/GG genotype,or G allele was associated with an increased risk of DR and DNR (P < 0.05).Moreover,GLIS3 rs7034200 CC,AC/CC genotype,or C allele was associated with an increased risk of DR and DNR (P < 0.05).Conclusion In the patients in Northeast China,the polymorphisms in GLIS3 rs7041847 and rs7034200 were correlated with type 2 diabetes mellitus,while GLIS3 may not be associated with the susceptibility to diabetic retinopathy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Observational study
/
Risk factors
Language:
Chinese
Journal:
Journal of China Medical University
Year:
2017
Type:
Article
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