Risk Factors for Postoperative Nausea and Vomiting in Gynecological Patients Administered Prophylactic Antiemetics / 中国医科大学学报

ABSTRACT

Objective To study the risk factors for postoperative nausea and vomiting (PONV) in gynecological patients administered prophylactic antiemetics.Methods A total of 1 000 gynecological surgical cases were reviewed.Data on patient characteristics,anesthesia,surgeries,and 1st postoperative day nausea and vomiting were collected and analyzed statistically.Results Multivariate logistic regression analysis included a history of motion sickness,the use of an analgesic pump,the duration of anesthesia,and the use of neostigmine.The odds ratios (ORs),in decreasing order,were that of a history of motion sickness [OR =1.953,95％ confidence interval (CI)1.404-2.716],the use of neostigmine (OR =1.831,95％ CI1.203-2.786),the use of an analgesic pump (OR =1.472,95％ CI1.017-2.129),and the duration of anesthesia (OR =1.256,95％ CI1.058-1.492).The predictive model was described by the following equationP=1/(1+e(1623-0.669X1-0.386X2-0.228X3+0.605X4)).Tne predictive accuracy of this model for the incidence of PONV in gynecological patients was 70.6％,and the area under the receiver operating characteristic curve for the predictive result was 0.642.Conclusion The independent risk factors for PONV in gynecological patients administered prophylactic antiemetics are a history of motion sickness,the use of neostigmine,the use of an analgesic pump,and the duration of anesthesia,in decreasing order of significance.