Fluorescein and Indocyanine Green Angiography of Choroidal Tumors

ABSTRACT

Fluorescein angiography (FAG) has been widely used in the diagnostic evaluation of choroidal tumors. Indocyanine green angiography (ICGA), which permits better visualization of choroidal vasculature than FAG, has been recently introduced into clinical practice. FAG and ICGA of 13 patients with choroidal tumors were assessed. These included 4 patients with choroidal nevus,4 with malignant melanoma, 2 with metastatic choroidal tumor,and 3 with choroidal hemangioma. In choroidal nevus, ICGA showed persistent hypofluorescence with clear delineation of the lesion in the late phase. Characteristic fluorescein angiographic feature of choroidal melanoma was hyperfluorescence in the late phase. However, the fluorescence of melanoma varied from hypo-,to hyperfluores- cent in the late phase of the ICGA. In choroidal metastatic tumor, FAG showed the typical pinpoint hyperfluorescence in the early phase and the diffuse leakage with serous detachment in the late phase. ICGA showed the hypofluo- rescence throughout the whole phases. In choroidal hemangioma, FAG and ICGA showed complete dye filling of the hemangioma with more denser hyperfluorescence in the early phase than in the late phase. In all patients, the lesion was better defined on the ICGA than on the FAG. This study suggests that ICGA combined with FAG may be useful in differentiating various choroidal tumors.