Efficacy of Omental Implantation of Autologous Splenic Segments after Splenectomy for Traumatic Rupture / 中国医科大学学报

ABSTRACT

Objective To evaluate the feasibility and efficacy of autologous splenic segment implantation after splenectomy for traumatic rupture. Methods This study included 42 patients with traumatic splenic rupture who were treated between July 2014 and August 2016 at the Affiliated Central Hospital of Shenyang Medical College. The patients were divided into an observation group (n = 23) and a control group (n = 19). Informed consent was provided by the patient or family members. The control group underwent routine splenectomy, and the observation group underwent implantation of autologous spleen segments after splenectomy. Results The operative time in the observation group was significantly longer than in the control group (P < 0.05). The intraoperative blood loss,time to postoperative return to oral feeding,and length of hospital stay were not statistically different (P > 0.05). The rate of postoperative wound infections in the observation group was significantly lower than in the control group (P < 0.05). All spleen segments developed well in the observation group. At 30 postoperative days,platelets were increased in both groups,but the level in the observation group was significantly lower than in the control group (P < 0.05). IgG,IgM,and IgA levels were significantly higher in the observation group than in the control group at 28 postoperative days (P < 0.01). CD3+ and CD4+/CD8+ levels were significantly higher in the observation group than in the control group at 14 and 28 postoperative days (P < 0.01). Conclusion Implantation of autologous spleen segments after splenectomy for trauma could be feasible and effective.