Role of the Subchondral Bone in Osteoarthritis / 中国医科大学学报

ABSTRACT

Temporomandibular joint osteoarthritis (OA) is the most severe type of temporomandibular joint disorder of the oral and maxillofacial region. This disorder has a high incidence, and its main characteristic is articular cartilage injury, accompanied by changes in the synovium and subchondral bone. The role of the changes in the subchondral bone in the development and progression of OA has attracted attention in recent years, and the importance of the subchondral bone has been recognized. At present, the subchondral bone has been considered a promising target for the treatment of OA. This manuscript summarizes the research progress in the pathological changes of the cartilage bone in OA, and its mechanism, which would be helpful for the treatment of this disease.