Protective effect of interleukin-1 receptor antagonist on intestinal ischemia-reperfusion induced injury in rats / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 365-370, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-705048
ABSTRACT
Aim To explore the effects of interleukin-1 receptor antagonist (IL-1Ra) on intestinal ischemia-reperfusion (I/R) induced injury in rats. Methods Thirty-five male SD rats were randomly divided into sham operation group (S), model group (I/R), dif-ferent dosage drug groups(C1,C2,C3). Rat intesti-nal I/R model was established via clamping the superi-or mesenteric artery (SMA). After 1 h of ischemia, the arterial clamps were released for 1 h of reperfusion. 10,20,50 mg·kg-1of IL-Ra was injected via caudal vein 15min before reperfusion. Results After 2 h of I/R,compared with S group,I/R group rats exhibited severe damage on the intestinal mucosa, increase in MDA content, decrease in SOD activity, and signifi-cant release of TNF-α, IL-1β, IL-6. The results showed that, following the injection of IL-1Ra after clipping superior mesenteric artery, damage of the in-testinal mucosa was obviously relieved in different dos-age drug groups. Furthermore, there was different de-gree of relief on oxidative stress and inflammatory re-sponses. Conclusion IL-1Ra showed obvious protec-tive effect on intestinal I/R induced injury by relieving oxidative stress and inflammatory response,and it may potentially be used in the clinical treatment of intestinal I/R injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2018
Type:
Article
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