Research progress of mitochondria in diabetic cardiomyopathy / 中国药理学通报

ABSTRACT

Diabetic cardiomyopathy (DCM) is one of the major cardiovascular complications of diabetes mellitus. Currently, there is a lack of effective treatment for DCM,and its pathophys-iology is quite complex. Mitochondria are the main source of car-diomyocyte energy and play an important role in regulating ener-gy metabolism. Mitochondria are swollen and fragmented in dia-betic patients, leading to impaired mitochondrial function, sug-gesting that mitochondrial damage and dysfunction may play an important role in the pathogenesis of DCM. In this paper, the relationship between mitochondrial damage and the pathogenesis of DCM was reviewed from the aspects of abnormal mitochondrial energy metabolism,mitochondrial oxidative stress enhancement, mitochondrial kinetics,mitochondrial heart lecithin change,and mitochondrial calcium disorder.