A Case of Ectopic CD7(+) Congenital Monocytic Leukemia
Journal of the Korean Pediatric Society
;
: 1003-1007, 1999.
Article
in Korean
| WPRIM
| ID: wpr-70507
ABSTRACT
Congenital acute leukemia is a rare disorder with approximately 200 cases reported. It is defined as a childhood leukemia occurring at birth or before 1 month of age at a rate of 1%. Acute leukemias are generally classified according to morphology, cytochemistry and cell surface marker expression. Most leukemias conform to an ordered lineage-specific pattern of gene expression, but a small subset of leukemias appears not to follow lineage restriction. Several reports revealed a subgroup of acute myelogenous leukemia(AML) that expresses CD7, a cell surface marker expressed early during T lineage differentiation, especially in less differentiated AML subtypes. We report a rare case of CD7(+) congenital monocytic leukemia(M5a) with detailed immunophenotypic and cytochemical characterization in an 8 week-old female. She had central nervous system (CNS) involvement at diagnosis. Chromosomal analysis revealed a mosaicism with 46,XX,-6,de1(7) (q21),t(19;21)(q13.3;q22)/46,XX, that has not been reported.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia
/
Gene Expression
/
Central Nervous System
/
Parturition
/
Diagnosis
/
Histocytochemistry
/
Mosaicism
Type of study:
Diagnostic study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Journal of the Korean Pediatric Society
Year:
1999
Type:
Article
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