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Non-hypoglycemic effect of metformin in renal protection:a literature review / 中国药理学通报
Chinese Pharmacological Bulletin ; (12): 593-596, 2018.
Article in Chinese | WPRIM | ID: wpr-705090
ABSTRACT
The effectiveness,safety and economy of metformin on type 2 diabetes mellitus therapy are well recognized, which has been used as the first-line oral hypoglycemic agent in recent dec-ades. Apart from hypoglycemic effect, recent studies show that metformin can exert renal protection via the mechanisms of auto-phagy induction, anti-senescence, antioxidative stress, against endoplasmic reticulum stress,anti-inflammation, and anti-fibro-sis through AMPK dependent or independent pathway, which prompt its therapeutic potential in acute kidney injury and chron-ic kidney disease. The non-hypoglycemic nephroprotective effects as well as their underlying mechanisms of metformin are summarized in this review.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2018 Type: Article