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Effect of extraction of saffron crocus on mitochondrial dynamics in ischemia/reperfusion rats / 中国药理学通报
Chinese Pharmacological Bulletin ; (12): 770-775, 2018.
Article in Chinese | WPRIM | ID: wpr-705125
Responsible library: WPRO
ABSTRACT
Aim To investigate the protection mecha-nism of the extraction of the saffron crocus in ischemia/reperfusion rats. Methods Hematoxylin-eosin stai-ning, electron microscopy, and neurological assess-ments were performed in a transient middle cerebral ar-tery occlusion ( tMCAO ) rat model. The role of dy-namin-related protein 1 ( Drp1 ) and optic atrophy 1 ( Opa1 ) , the two key regulators of mitochondrial fis-sion and fusion in ischemic brain damage in vivo were observed. Results In ischemia/reperfusion rats, the extraction of the saffron crocus increased the level of protein Opa1 and decreased the level of protein Drp1 . Conclusions Inhibition of Drp1 and promotion of Opa1 , which means to maintain balancing mitochondri-al dynamics, is proposed as an efficient strategy for neuroprotection against ischemic brain damage.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2018 Type: Article