Metabolic disorder of fatty acids and bile acids caused by organochlorine pesticides:research progress / 中国药理学与毒理学杂志

ABSTRACT

Organochlorine pesticides(OCP)exist widely in the environment,which may threaten human health and cumulate for years once absorbed in the body.OCP metabolites in the body are associated with metabolic disorders.In vivo and in vitro exposure of OCP could enhance hepatic fatty acid synthesis, and interfere in the β-oxidation of fatty acids by impairing the function and structure of mitochondria in hepatocytes. Moreover, OCP can increase secondary bile acid formation by modulating of gut microbiota and reduceing ileal bile acid re-absorption,resulting in compensatory increase of hepatic bile acid synthesis. This review summarizes the mechanism of fatty acid and bile acid metabolic abnormalities caused by OCP.