Research progress in role of PARP-1 in inflammatory pulmonary diseases / 中国药理学与毒理学杂志

ABSTRACT

Poly(ADP-ribose)polymerase-1(PARP-1) is a ribozyme widely expressed in eukaryotic cells with significant biological activity, the activation of which is involved in the signal transduction of inflammatory pulmonary disease. In this paper, we review PARP-1 involvement in lung inflammation regulation and its prospects for treatment of diseases in terms of the structure and function of PARP-1, inflammation of the signal conditioning,regulation of lung inflammation disease and progress in inhibitor research. This review is intended to further clarify the pathogenesis of pulmonary inflammatory disease, and to provide reference for the prevention and treatment of the disease.