Unilateral Pigmented Extramammary Paget's Disease of the Axilla Associated with a Benign Mole: A Case Study and a Review of Literature
Korean Journal of Pathology
;
: 292-296, 2014.
Article
in English
| WPRIM
| ID: wpr-70529
ABSTRACT
Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease affecting skin that is rich in apocrine sweat glands such as the axilla, perianal region and vulva. It most commonly occurs in postmenopausal women and presents as a superficial pigmented scaly macule, mimicking a melanocytic lesion. The histological presentation is adenocarcinoma in situ with an increased number of melanocytes scattered between the Paget's cells. Therefore, PEMPD may be misdiagnosed as a melanocytic tumour both clinically and histologically. The tumour cells are usually positive for cytokeratin 7, epithelial membrane antigen, Cam 5.2, HER2, and mucicarmine stain while S100 and human melanoma black-45 highlight the processes of reactive dendritic cells. The association between Paget's cells and intratumoural reactive melanocytes is still unclear. We report our first case of PEMPD associated with an intradermal naevus involving the axilla in a 63-year-old woman.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Axilla
/
Sweat Glands
/
Vulva
/
Dendritic Cells
/
Adenocarcinoma
/
Paget Disease, Extramammary
/
Mucin-1
/
Keratin-7
/
Melanocytes
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2014
Type:
Article
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