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Research advances in antiplatelet activation of water soluble compounds in Salvia miltiorrhiza / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology ; (6): 302-302, 2018.
Article in Chinese | WPRIM | ID: wpr-705325
ABSTRACT
Platelets are fragments of cytoplasm that are released from the mature megakaryocyte of the bone marrow.The main function of platelets is coagulation and hemostasis.Platelets play a central role in formation of pathological thrombosis. Many ischemic diseases are caused by excessive activa-tion of platelets, which can lead to thrombosis and death. Salvia miltiorrhiza Bunge, the dry roots and rhizomes of the Salvia miltiorrhiza plants,includes some water-soluble compounds,which play positive effects on diverse diseases such as neurodegenerative diseases, diabetic complications or cardiovas-cular diseases.In this paper,the components of the water-soluble in Salvia miltiorrhiza,as well as the applications in thrombotic diseases are summarized. The results show that water-soluble compounds include salvianolic acid A,salvianolic acid B,protocatechuic aldehyde, Danshensu,etc.The water-soluble compounds are applied to ischemic stroke,myocardial infarction and other diseases caused by thrombus. We also discussed the mechanisms of water-soluble compounds on the platelets based on our research results and the data obtained from references. The results indicate that water soluble compounds in Salvia miltiorrhiza play the antiplatelet and antithrombotic effects via different mechanisms, for example, salvianolic acid A inhibits platelet aggregation without promoting bleeding by increasing cAMP, inhibiting phosphoinositide 3-kinase (PI3K) and affecting GPCRs (G protein-coupled receptors) signaling path-ways; salvianolic acid B inhibit platelets as a P2Y12 antagonist and PDE inhibitor; Danshensu inhibits platelet activity may be related to inhibition of calcium influx.In conclusion,thrombotic diseases seriously affect human life and health. The existing antiplatelet drugs have some disadvantages. For example, aspirin may cause intracranial hemorrhage, and clopidogrel may play a slower role. Salvia miltiorrhiza as a traditional Chinese medicine has positive pharmacological activity and exerts antiplatelet aggrega-tion through different mechanisms.In the future,we will develop the new drugs which prevent and treat thrombotic diseases with the further study of the pharmacological effects and mechanisms of Salvia miltiorrhiza.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Pharmacology and Toxicology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Pharmacology and Toxicology Year: 2018 Type: Article