Study on Microbial Limit Test Methods for Three Preparations Containing Chlorhexidine Acetate / 中国药师
China Pharmacist
; (12): 2071-2073, 2017.
Article
in Zh
| WPRIM
| ID: wpr-705429
Responsible library:
WPRO
ABSTRACT
Objective:To establish the microbial limit test methods for three preparations containing chlorhexidine acetate. Meth-ods:The validation of microbiological limit test for three preparations including chlorhexidine acetate solution, chlorhexidine acetate ointment and chlorhexidine acetate cream was carried out respectively using the conventional method,dilution method,membrane filtra-tion method and neutralization method. Results:The recovery rates of five strains in the verification of counting method by membirane filtration and nearailzation method were more than 50%. Every positive test micrcorganism could be detected while negative control bacteria could not grow in the examination of control bacteria.Conclusion:The membrane filtration method can be used for the deter-mination of control bacteria for chlorhexidine acetate solution and chlorhexidine acetate ointment,and the neutralization method can be applied in the determination of control bacteria for chlorhexidine acetate cream.
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Index:
WPRIM
Language:
Zh
Journal:
China Pharmacist
Year:
2017
Type:
Article