Pharmacokinetics and Tissue Distribution of Curcumin in Turmeric Capsules in Rats / 中国药师
China Pharmacist
;
(12): 65-68, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-705452
ABSTRACT
Objective:
To study the pharmacokinetics and tissue distribution characteristics of curcumin in turmeric capsules in rats.Methods:
SD rats were given the capsules at the dose of 5 g· kg-1 , and plasma, liver, kidney, stomach and small intestine were withdrawn.Curcumin was determined by HPLC .Results:
The results showed that the linear range of curcumin was 0.1-10μg· ml-1 .The metabolic results in vivo showed that t1/2 was (25.13 ±5.63) h, tmax was 0.50 h, Cmax was (0.44 ±0.01)μg· ml-1 , and AUC0-t was (2.11 ±0.04)μg· ml-1 · h.Meanwhile, curcumin could be detected out in gastrointestinal tract , liver and the other or-gans.Conclusion:
Turmeric capsules can make curcumin rapidly absorbed and effectively distributed in various tissues of rats .The re-sults provide evidence for the clinical medication .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2018
Type:
Article
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