Preparation and Characterization of Celecoxib-loaded Micelles / 中国药师
China Pharmacist
;
(12): 82-88, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-705457
ABSTRACT
Objective:
To prepare celecoxib-loaded micelles with polyethylene glycol monomethyl ether-polylactic acid ( mPEG-PLA) block copolymer as the carrier material and evaluate the physical and chemical properties .Methods:
Celecoxib-loaded micelles were prepared by a film dispersion method .The micelle formula and preparation process were screened by single factor experiment and further optimized by Box-Behnken response surface method .The physical and chemical properties of celecoxib-loaded micelles such as microscopic morphology , particle size distribution and zeta potential were evaluated .The in vitro drug release of celecoxib-loaded mi-celles was investigated by dynamic membrane dialysis .Results:
Celecoxib-loaded micelles prepared according to the optimized formula showed the following propertiesthe particle size distribution was (35.6 ±15.1) nm, PdI was (0.152 ±0.05), and the zeta potential was (-24.6 ±2.9) mV.In 0.5%SDS phosphate buffered saline (pH 6.8), the in vitro cumulative release of celecoxib-loaded mi-celles reached up to 81 .5%in 24 h.Conclusion:
It is simple and feasible to prepare celecoxib-loaded micelles by the thin film dis-persion method .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2018
Type:
Article
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