Effects of Rosuvastatin Calcium at Different Doses Combined with Basic Treatment in Elderly Patients with Unstable Angina Pectoris / 中国药师

ABSTRACT

Objective:To observe the effects of rosuvastatin calcium at different doses combined with the basic treatment in elderly patients with unstable angina pectoris ( UAP) , and investigate the influence on the serum inflammatory factors .Methods:Totally 82 ca-ses of elderly patients with UAP were divided into the low dose group and the high dose group randomly .In addition to the basic treat-ment, the low dose group was given rosuvastatin calcium tablets 10mg, once per night, and the high dose group was given rosuvastatin calcium tablets 20 mg, once per night .The serum inflammatory factors and blood lipid levels of the two groups before the treatment and after 3-months treatment were compared .The therapeutic effect , frequency and duration of attack and the incidence of adverse events of the two groups were evaluated .Results:After the treatment , the levels of TC , TG and LDL-C in both groups significantly decreased , and that of HDL-C increased (P<0.05), and the blood lipid indexes in the high dose group were better than those in the low dose group (P<0.05).The levels of TNF-α, IL-6 and TGF-β1 decreased significantly after the treatment (P<0.05), and level of these indexes in the high dose group were much lower than that in the low dose group (P<0.05).The total effective rate in the high dose group was 95.43％, which was much higher than that (77.50％) in the low dose group (P<0.05).The frequency and duration of angina pectoris in the high dose group were both lower than those in the low dose group (P<0.05).The incidence of adverse events in the two groups showed no statistically significant difference (P>0.05).Conclusion:High dose rosuvastatin calcium combined with the basic treatment can effectively improve the blood lipid levels and serum inflammatory factors in the elderly patients with UAP , which exhibits good clinical curative effect .