Optimization of Preparation Technology of Rutin Nanoemulsion by Central Composite Design-Response Surface Method / 中国药师
China Pharmacist
;
(12): 204-208, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-705490
ABSTRACT
Objective:
To optimize the preparation technology of rutin nanoemulsion.Methods:
The pseudoternary phase diagram of rutin nanoemulsion under the condition of different Kmwas drawn. With the drug loading and the particle size as the independent var-iables,and the percent of oil and the weight ratio of surfactant to cosurfactant as the dependent variables, the blank formula of rutin nanoemulsion was optimized by central composite design-response surface method.Results:
The optimal formula was as followsthe ra-tio of ethyl oleate, cremopher RH40,1,2-propanediol and water was 7 13 5 25. The average particle size of the prepared rutin nanoemulsion was 26.51 nm,and the drug loading was 8.97 mg·ml-1.Conclusion:
The central composite design-response surface method can obtain a good formula of rutin nanoemulison,and the model has a good predictive function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Pharmacist
Year:
2018
Type:
Article
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