Laxative Function of Shutong Digestion Powder in Mice / 中国药师

ABSTRACT

Objective:To observe laxative function of Shutong digestion powder in mice with constipation by experimental means to provide reference for clinical research. Methods:ICR mice were used as the research objects,and the mice model of constipation was induced by oral administration of loperamide hydrochloride. Totally 120 ICR mice were divided into two groups(experimental group 1 and experimental group 2) with 60 in each,and each group was divided into 6 subgroups by random numberthe normal control group, the model control group,the positive control group(mosapride citrate tablets,2.25×10 -3g·kg-1),Shutong digestion powder group respectively at low(1 g·kg-1),medium(3 g·kg-1) and high dose(9 g·kg-1) with 10 ones in each. Drugs were given by intra-gastric administration,once a day,for 7 days. In the first experiment group,mice were subjected to defecation test,and the stool traits and the time of first defecation in each group were observed and recorded. In the experimental group 2,small intestine motility test was conducted to observe and record the ink advancing rate in intestine. Results:Compared with the model control group,there was no sig-nificant difference in the body weight of mice in each Shutong digestion powder group(P>0.05),and the time for the first row of me-lena significantly decreased(P<0.05 or P<0.01). The rate of small intestine propulsion increased except for Shutong digestion pow-der group at low dose,and the other groups had significant differences (P<0.05 or P<0.01). Compared with the positive control group,there was no significant difference in the body weight and the first defecation time between Shutong digestion powder groups and the control group (P>0.05). The ink advancing rates of Shutong digestion powder groups were lower than that of the positive control group (P<0.05 or P <0.01). Conclusion:Shutong digestion powder has good promotion function for defecation and intestinal peri-stalsis.