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Uncertainty Evaluation for the Determination of Dexamethasone in Cosmetics by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry / 中国药师
China Pharmacist ; (12): 539-542,546, 2018.
Article in Chinese | WPRIM | ID: wpr-705583
ABSTRACT

Objective:

To evaluate the measurement uncertainty in the determination of dexamethasone in cosmetics by ultra per-formance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).

Methods:

The uncertainty caused by various factors in the whole determination process was analyzed,including weighing,standard solution preparation,calibration fitting,extraction and de-termination.

Results:

The combined uncertainty in the determination of dexamethasone in cosmetics was 0.75 μg·g-1and the ex-panded uncertainty was 1.5 μg·g-1. The content of dexamethasone in cosmetics was(20.4 ± 1.5) μg·g-1(k=2,confidence inter-val p=95%).

Conclusion:

The uncertainty of the method is mainly caused by standard solution preparation and calibration fitting.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2018 Type: Article