Uncertainty Evaluation for the Determination of Dexamethasone in Cosmetics by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry / 中国药师
China Pharmacist
;
(12): 539-542,546, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-705583
ABSTRACT
Objective:
To evaluate the measurement uncertainty in the determination of dexamethasone in cosmetics by ultra per-formance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS).Methods:
The uncertainty caused by various factors in the whole determination process was analyzed,including weighing,standard solution preparation,calibration fitting,extraction and de-termination.Results:
The combined uncertainty in the determination of dexamethasone in cosmetics was 0.75 μg·g-1and the ex-panded uncertainty was 1.5 μg·g-1. The content of dexamethasone in cosmetics was(20.4 ± 1.5) μg·g-1(k=2,confidence inter-val p=95%).Conclusion:
The uncertainty of the method is mainly caused by standard solution preparation and calibration fitting.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS