Preparation and Dissolution of Loratadine Nanosuspension Lyophilized Powder / 中国药师
China Pharmacist
;
(12): 809-813, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-705598
ABSTRACT
Objective:
To prepare loratadine nanosuspension lyophilized powder (LTD-NLP) and investigate the dissolution and stability.Methods:
LTD-NLP was prepared by an anti-solvent precipitation method; the particle size and morphology were characterized by a laser nanometer particle sizer and a transmission electron microscope (TEM). The optimal lyophilized protective agent was screened out; the dissolution and stability of LTD-NLP were determined by HPLC.Results:
The average particle size of LTD-NLP was 175.6 nm with PDI of 0.200, and the zeta potential was -56.3 mV. The shape of LTD-NLP was spherical. The nanosuspension lyophilized with 10% sucrose presented optimal properties. The dissolution of LTD-NLP was greater than raw material, and LTD-NLP had good stability at 4℃.Conclusion:
The anti-solvent precipitation method for LTD-NLP is simple,and the product is expected to become a new preparation of loratadine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2018
Type:
Article
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