Determination of Crystal Type α in Glycine by Powder X-ray Diffraction / 中国药师
China Pharmacist
;
(12): 1759-1761, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-705699
ABSTRACT
Objective:
To determine the content of crystal type α in glycine by X-ray power diffraction technique to provide evi-dence for the polymorphic research.Methods:
A calibration curve was established by using the characteristic peak ratio of glycine form α at 2θ=19. 1° to form γ at 2θ=25. 4° as the quantitative parameter to determine the content of crystal type α.Results:
The charac-terization figures of form α and form γ were obtained. The linear range of form α was 1%-99% (r=0. 996 7), and the average recov-ery was 102. 8% with the RSD of 4. 0% (n=9).Conclusion:
X-ray powder diffraction method is a feasible analytical method for the quantitative determination of form α and form γ of glycine with simple,sensitive and accurate properties.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2018
Type:
Article
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