Preparation and Quality Evaluation of Celecoxib Hotmelt Pressure Sensitive Adhesive / 中国药师

ABSTRACT

Objective: To prepare celecoxib hotmelt pressure sensitive adhesive (HMPSA), and investigate the quality. Methods:Celecoxib HMPSA was prepared using styrene-isoprene-styrene triblock copolymer (SIS) as the chief material, and the quality of HMP-SA was inspected with stickiness, peel strength, melt temperature and percutaneous permeation rate in vitro as the indices. Results:The stickiness of celecoxib HMPSA was (17.79 ±0.25)N, the peel strength was (2.81 ±0.49) N·cm-2, the melt temperature was 90. 8 ± 1. 9℃, and the percutaneous permeation rate in 24h was (18. 77 ± 1. 51) mg·cm-2. Conclusion: The HMPSA is suitable for the preparation of TDDS of celecoxib.