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Prognostic significance of myocardial markers and echocardiography in elderly patients with sepsis / 中国医师杂志
Journal of Chinese Physician ; (12): 644-648, 2018.
Article in Zh | WPRIM | ID: wpr-705876
Responsible library: WPRO
ABSTRACT
Objective To explore the relationship between those myocardial markers serum cardiac troponin T (cTNT),serum cardiac troponin I (cTNI),N-terminal pro-brain natriuretic peptide (NT-proBNP),echocardiography and myocardial injury in the oldest-old septic patients,as well as to evaluate prognosis in the oldest-old septic patients.Methods 140 oldest-old septic patients hospitalized in Beijing Friendship Hospital from January 1 st,2015 to Jun 31st,2017 were collected and analyzed retrospectively.They were divided into survival group (90 cases) death group (50 cases)according to their survival time.Serum cTNT,cTNI and NT-proBNP level at 1,3 and 7d post-diagnosis were collected and echocardiography left ventricular diastolic diameter (EDD),left ventricular systolic diameter (ESD),right ventricular diameter (RV),left ventricular ejection fraction (EF) was performed.Results 140 oldest-old septic patients were enrolled in the analysis.There were 90 cases in survival group and 50 cases in death group.Mean values of cTNT,cTNI,NT-proBNP,EDD,ESD in survival group were obviously higher than those in death group (P < 0.05),left ventricular ejection fraction (LVEF) in survival group was lower than that in death group (P < 0.01).But there were no difference in E/A and RV between survival group and death group (P > 0.05).There were positive correlation between cTNT,cTNI,NT-proBNP and EDD,ESD (P < 0.05),negative correlation between cTNT,cTNI,NT-proBNP and LVEF (P < 0.05),and no correlation between cTNT,cTNI,NT-proBNP and E/A,RV (P >0.05).There were obviously correlation between cTNT,cTNI,NT-proBNP,EDD,ESD and mortality rate (OR > 1,P < 0.05).It was shown the prognosis value of cTNT,cTNI,NT-proBNP,EDD,ESD to mortality rate in oldest-old septic patient.The prognosis value was cTNT > NT-proBNP > cTNI > EDD > ESD.Conclusions There were obviously correlation between cT NT,cTNI,NT-proBNP,EDD,ESD and myocardium restrain,heart dysfunction as well as mortality rate.cTNT was the best prognosis indicator in sensitivity,and NT-proBNP was the best prognosis indicator in specificity.The combination of cTNT and NT-proBNP can better forecast the prognosis of the oldest-old septic patient.
Key words
Full text: 1 Index: WPRIM Type of study: Prognostic_studies Language: Zh Journal: Journal of Chinese Physician Year: 2018 Type: Article
Full text: 1 Index: WPRIM Type of study: Prognostic_studies Language: Zh Journal: Journal of Chinese Physician Year: 2018 Type: Article