Study on the correlation between oxidative stress and pain after laparoscopic myomectomy / 中国医师杂志

ABSTRACT

Objective To investigate the correlation between oxidative stress and pain after laparoscopie myomectomy.Methods 84 patients with uterine myoma who were treated in Changsha Hospital of traditional Chinese Medicine from March 2014 to March 2017 were enrolled in the study.The patients were divided into the control group (n =42) and the observation group (n =42) according to the random number table method.The patients in the control group were treated with conventional laparotomy hysteromyoma expetion,and the patients in the observation group were treated by laparoscopic myomectomy.The levels of oxidative stress indexes [reactive oxygen species (ROS),malondialdehyde (MDA),advanced oxidation protein products (AOPP)] and pain indexes [interleukin-6 (IL-6),substance P (SP),prostaglandin E2 (PGE2) and visual analogue scale (VAS) score] were compared between two groups before operation,1 d after operation and 3 d after operation.Pearson correlation analysis was used to analyze the correlation between oxidative stress and pain.Results The levels of plasma ROS,MDA and AOPP in the two groups 1 d after operation and 3 d after operation were higher than those before operation (all P ＜ 0.05),the levels of plasma ROS,MDA and AOPP in observation group 1d after operation and 3 d after operation were significantly lower than in the control group (all P ＜ 0.05).The levels of serum IL-6,SP,PGE2 and VAS score in the two groups 1 d after operation and 3 d after operation were all higher than those before operation (all P ＜ 0.05),the levels of serum IL-6,SP,PGE2 and VAS score in observation group after 1 d and 3 d after operation were all lower than those in control group (all P ＜ 0.05).The results of Pearson correlation analysis showed that ROS,MDA and AOPP was positively correlated with PGE2 (P ＜ 0.05).Conclusions Laparoscopic myomectomy can effectively reduce the oxidative stress response to postoperative hysteromyoma and relieve postoperative pain,and oxidative stress is positively correlated with PGE2 after operation.