DTI quantitative evaluation of functional changes after acute traumatic spinal cord injury in rats / 中国医学影像技术
Chinese Journal of Medical Imaging Technology
; (12): 807-811, 2018.
Article
in Zh
| WPRIM
| ID: wpr-706333
Responsible library:
WPRO
ABSTRACT
Objective To explore the value of DTI quantitative parameters in evaluating neurological function changes of acute traumatic spinal cord injury (TSCI)in rat models.Methods The modified Allen's dropping weight technique was used to establish TSCI rat models.Then the rats were divided into mild injury group,moderate injury group and severe injury group (each n=10).DTI examination and Basso-Beattie-Bresnahan (BBB) score were performed pre-TSCI and 0 h,6 h,24 h,3 day,7 day and 14 day post-TSCI,respectively.The BBB scores and DTI parameters,including FA,mean apparent diffusivity (MD),radial diffusivity (RD) and axial diffusivity (AD) were measured and compared among groups.The correlation between BBB scores and the parameters was evaluated.Results The differences of FA,MD and RD value were statistically significant among varying injury degree groups and different time points after TSCI (all P<0.05).AD value had statistical difference among different time points (F=12.720,P<0.001),whereas no difference was found among varying injury degree groups (F=0.469,P=0.630).FA and MD values decreased while RD increased 0 h post-TSCI.Then RD and MD increased continuously,whereas FA decreased continuously until 24 h post TSCI (all P<0.05),and the parameters kept stable after 24 h post-TSCI (all P> 0.05).The BBB scores were lowest on 0 h post-TSCI,then maintained increasing (all P<0.05).In addition,the BBB scores and MD values had good correlation (r=0.958,P< 0.01).Conclusion DTI can quantitatively evaluate function changes of TSCI in rat models.Moreover,treatment within 24 h post-TSCI might be recommended for TSCI therapy.
Full text:
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Index:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Chinese Journal of Medical Imaging Technology
Year:
2018
Type:
Article