Impact of Manganese Concentration on Manganese-enhanced Magnetic Resonance Imaging in Different Colon Cancer Cell Lines / 中国医学影像学杂志

ABSTRACT

Purpose Manganese (Mn) concentration is one of the basic factors that have impact on manganese-enhanced magnetic resonance imaging (MEMRI) enhancement of neoplasm.This study aims to elucidate the impact of Mn concentration on enhancement of MEMRI in different colon cancer cells.Materials and Methods The human colon cancer cell SW620 with high metastatic potential,SW480 with low metastatic potential and the normal cell CCD841 CoN were performed MEMRI under different Mn concentrations (0,0.05,0.10 and 0.20 mmol/L) in vitro.The average values ofT1 shortening were calculated by T1 map scan in different cells under different Mn concentrations.Results When the concentration of Mn was 0.10 and 0.20 mmol/L,the average value of T1 shortening of the three cell lines was SW620＞SW480＞CCD841 CoN (P＜0.01).There was no significant difference in the average T1 value of the normal cell lines under different Mn concentrations (0.05,0.10,0.20 mmol/L) (P＞0.05).The average T1 value of two tumor cells increased with the increase of Mn concentration.Under the condition of high Mn concentration (0.10 and 0.20 mmol/L),SW620 took in more Mn than SW480.Conclusion Colon cancer cells increase Mn uptake with increasing of Mn concentration.MEMRI can distinguish colon cancer cells with different metastatic potential.