Multi-slice Spiral CT Features and Correlation with Different Histological Grades in Pancreatic Neuroendocrine Tumors / 中国医学影像学杂志

ABSTRACT

Purpose To explore the correlation between multi-slice spiral CT (MSCT) findings of pancreatic neuroendocrine tumor (pNET) and different histological grades,so as to improve the diagnostic accuracy.Materials and Methods MSCT data of 35 pathologically confirmed pNET were retrospectively analyzed.All patients underwent CT plain scan and three-phased contrast-enhanced CT scan.The imaging features and the enhanced parameters in each stage were analyzed.Results Among the 35 pNET,there were 15 G 1,15 G2 and 5 G3.There was no statistically significant difference in age,gender and endocrine function among different grades (P＞0.05).The number of lesions with intact capsule in G1,G2 and G3 was 11,5 and 0,respectively;the number of lesions with cystic change or necrosis was 3,9,and 4,respectively;and the number of lesions with sign of malignancy (locally invasion or metastasis) was 1,1 and 4,respectively.The differences in completeness of capsule,cystic change or necrosis and sign of malignancy among different grades were all statistically significant (P＜0.05).Multivariate analysis suggested that only peripancreatic tissue invasion or metastasis was significantly associated with pathological classification (OR=0.09,95％ CI 0.01-0.86,P＜0.05).The three-stage absolute enhanced degree and the enhanced percentage of pNET in different grades,as well as the relative enhanced degree between lesions in arterial phase and portal venous phase were all statistically significantly different (P＜0.05).Conclusion The MSCT findings of pNET with different pathological grades have certain characteristic.Peripancreatic tissue invasion or metastasis is associated with high-grade tumors,and CT features of different grades can contribute to the preoperative grading of pancreatic neuroendocrine tumors.