Correlations of bcl-2 expression with clinicopathological features in breast cancer
Yonsei Medical Journal
;
: 206-211, 1997.
Article
in English
| WPRIM
| ID: wpr-70663
ABSTRACT
To evaluate the prognostic significance of bcl-2, we investigated the correlation of bcl-2 expression with the established indicators of prognosis and tumor behavior in breast cancer. This study included a patient group of 91 histologically diagnosed female breast carcinomas. To determine the bcl-2 immunoreactivity, we used a monoclonal antibody directed against the bcl-2 protein by immunohistochemistry from paraffin-embedded tissue in a series of 91 women with breast cancer. Interpretable DNA histograms were obtained from 84 patients. The median age at diagnosis was 45.5 years and the median follow-up time was 30.5 months. Forty-eight (52.7%) cancers showed the bcl-2 immunoreactivity in the cytoplasm. The nonneoplastic portion of ductal epithelial cells and normal lymphocytes were usually stained with bcl-2 antibody. Estrogen receptors (ER)(p 0.05) and DNA ploidy (p > 0.05) were not related with it. The bcl-2 positive patients showed longer survival (p 0.05), nuclear grade (p > 0.05), ER status (p > 0.1) and PR status(p > 0.1) were not reliable indicators for overall survival except histologic grade (p < 0.05). Our results suggest that bcl-2 expression may be related to hormonal regulation and tumor differentiation in breast carcinoma. Larger patient study groups with a longer follow-up period will be helpful to clarify the prognostic significance of bcl-2.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast Neoplasms
/
Carcinoma in Situ
/
Receptors, Progesterone
/
Receptors, Estrogen
/
Carcinoma, Ductal, Breast
/
Proto-Oncogene Proteins c-bcl-2
/
Middle Aged
Limits:
Female
/
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
1997
Type:
Article
Similar
MEDLINE
...
LILACS
LIS