Relationship between the neutrophil to lymphocyte ratio and prehypertension / 中国综合临床

ABSTRACT

Objective To investigate the relationship between the ratio of neutrophils to lymphocyte and prehypertension and its clinical significance. Methods In May 2015,three thousand one hundred and twenty-six subjects who underwent physical examination in Tangshan People's Hospital Health Examination Center were enrolled in the study. 120 cases of pre hyperton were selected as the observation group,and 120 with normal blood pressure were used as the control group. The neutrophils and lymphocyte counts of the subjects were detected. The relationship among the two groups of test indicators,the ratio of neutrophils to lymphocyte counts and blood pressure was analyzed. Results The ratio of neutrophil and lymphocytes in the observation group was (2. 28± 0. 39), significantly higher than that in the control group ( 1. 41 ± 0. 32) ( t＝ 1. 196 P ＝0. 028). According to the different ratio of neutrophils / lymphocytes,the patients were divided into 3 groups,group A (1. 12 ± 0. 23), group B ( 1. 73 ± 0. 08), group C ( 2. 57 ± 0. 39), aling with the ratio increasing, the blood pressure increased,the systolic blood pressure of group A,B,C was (115±9) mmHg,(117±11) mmHg,(128 ±6) mmHg,respectively. The difference was statistically significant (F＝4. 404,P＝0. 013),the diastolic blood pressure of group A,B,C was (73±5) mmHg,(78±7) mmHg,(86±4) mmHg,respectively. The difference was statistically significant (F＝4. 553,P＝0. 027). Multivariate Logistic regression analysis showed that the ratio of neutrophils to lymphocytes was affected by systolic blood pressure,blood glucose,high density lipoprotein,BMI and triglyceride. Conclusion There is correlation between the ratio of neutrophil to lymphocyte and prehypertension, suggesting that inflammation may be involved in the occurrence and development of hypertension.