Observation on the efficacy of percutaneous drug penetration in the treatment of young patients with relapsed bacterias and pulmonary tuberculosis / 中国综合临床

ABSTRACT

Objective To evaluate the efficacy of percutaneous drug penetration in the treatment of young patients with relapsed positive pulmonary tuberculosis. Methods From June 2013 to May 2016,eighty-four cases of with relapsed bacterias and pulmonary tuberculosis treated in Hebei Chest Hospital were enrolled in the study and were randomly divided into the observation group and the control group, 42 cases in each group. Both groups were treated with conventional anti tuberculosis drug 2HRZES/6HRE, the patients in the observation group were treated with ultrasound conductometric instrument and ultrasound conductive gel patch (isoniazid 0. 1 g) for 1 time /d,20 min each time. The course lasted for 3 months. Results At the end of 1,3 and 8 months treatment,the rates of sputum negative conversion in the observation group were 45. 24%( 19/42),66. 07%( 28/42), 92. 86%( 39/42), which were significantly higher than those of the control group ((23. 81%( 10/42), 40. 48%( 17/42), 73. 81%( 31/42 )), the difference between the two groups was statistically significant (x 2＝4. 27,5. 79,5. 49,P＜0. 05). At the end of the 8 months,the obvious absorption rate of the lesion was 94. 48%(38/42),and the control group was 69. 05%(29/42). The difference between the two groups was statistically significant (x 2＝5. 97,P＜0. 05). At the end of 8 months,the curative rate of the observation group was 90. 48%, while that of the control group was 64. 29%. The difference between the two groups was statistically significant (x 2＝5. 97,P＜0. 05). Conclusion Percutaneous drug penetration has good safety. Combined with systemic chemotherapy,it can improve the treatment effect of young patients with relapsed bacterias positive pulmonary tuberculosis,and is worthy of promotion.