Effect of human placenta on ovarian function and endometrial receptivity in patients with ovarian dysfunction / 中国综合临床

ABSTRACT

Objective To investigate the effect of human placenta on ovarian function and endometrial receptivity in patients with ovarian dysfunction. Methods From January 2017 and August 2017, one hundred and twenty patients of ovarian hypofunction infertility who received therapy in Liuzhou Worker′s Hospital were selected and were randomly divided into observation group ( 60 cases) and control group ( 60 cases) ,the control group was treated with oral letrozole at the 2nd to 5th day of the menstrual cycle for 5 consecutive days,at the same time, vitamin E soft capsule was taken orally until the next menstrual cycle, the letrozole usage in the observation group was the same as that in the control group,and human placenta tablets were taken orally until the next menstrual cycle. Both groups were treated for 3 menstrual cycles continuously. The changes of luteinizing hormone (LH),follicle stimulating hormone (FSH),estradiol (E2),resistance index (RI),pulsation index (PI),endometrial thickness and shape during and after ovulation were compared between the two groups before and after treatment. The efficacy of ovulation induction,ovulation rate and pregnancy rate were compared. Results After treatment,two groups of FSH,E2 treatment were decreased significantly ( P<0. 05) ,the FSH,E2,in the observation group were significantly lower than those of the control group ((9. 62±1. 04)U/L vs. (12. 45±1. 13)U/L,(174.85±36.21)pmol/L vs. (188.69±27.92)pmol/L)(t=14.274,2.345,P<0.05),there were no obvious changes in LH in the observation group and the control group( P>0. 05);after treatment,the endometrial thickness in the observation group was significantly higher than that of the control group ((12. 25±0. 13)mm vs. (10. 97±0. 10)mm)(t=60. 452,P<0. 05); after treatment,the RI and PI of the two groups were significantly lower than those before treatment (P<0. 05),the RI,PI in the observation group were significantly lower than those of the control group ((0.54±0.03)vs. (0.59±0.03),(1.23±0.06)vs. (1.43±0.08))(t=9.129, 15. 492,P<0. 05);the total effective rate of ovulation induction in the observation group was significantly higher than that in the control group (93. 33％(56/60)vs. 75. 00％(45/60))(χ2=7. 566,P<0. 05); there was no significant difference in ovulation rate between the two groups ( P>0. 05) ,but the pregnancy rate in observation group was obviously higher than that of the control group ( 31. 67％ ( 19/60) vs. 15. 00 ( 9/60) ) (χ2=4. 658, P<0. 05 ) . Conclusion In patients with ovarian dysfunction in the application of human placenta effect is significant,which can effectively improve the ovarian function and endometrial receptivity, improve pregnancy rate,clinical application value is high.