Advances of granulocyte-macrophage colony-stimulating factor combinied with radio-therapy / 中国肿瘤临床

ABSTRACT

The granulocyte-macrophage colony-stimulating factor(GM-CSF)can effectively induce the proliferation of tumor-associat-ed immunocytes as a hematopoietic factor;therefore,the fact that GM-CSF can induce systemic antitumor immune responses has at-tracted much attention.Radiotherapy,as one of the main treatment approaches of cancer,can kill tumor cells directly,and has an ef-fect on anti-tumor immunity.Several clinical studies have shown that radiotherapy combined with the GM-CSF can induce an abscopal effect and confer favorable therapeutic effects for cancer.Herein,we review the research progress on GM-CSF,and radiotherapy com-bined with GM-CSF in tumor treatment.