Advances in the mechanism of IL-35 regulating the development of malignant tumors / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 529-534, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-706843
ABSTRACT
Interleukin-35 (IL-35) produced by regulatory T cells is a newly discovered inhibitory cytokine. It's a heterodimer consisting of IL-27βchain Epstein-Barr virus-induced gene 3 and IL-12αchain p35. In recent years, many studies have found that T cells, B cells, and tumor cells can secrete IL-35, which has a major inhibitory effect on the immune system. IL-35 plays an important role in tumor im-mune evasion and promotion of tumor progression and metastasis, and is an important factor which promotes the occurrence and de-velopment of tumors. Reducing IL-35 secretion may improve disease control, and it is very important to make a thorough inquiry into the role of IL-35 in regulating the activities of tumor cells. This review summarizes the molecular structure, biological functions, and regulatory roles of IL-35 in the development of malignant tumors. It is hoped that it can provide a novel perspective on the judgment of tumor prognosis and tumor targeted molecular therapy in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS