Effect of Ruineng nutritional fluid on nutritional status, immunological function and prognosis in severe patients with mechanical ventilation / 中国中西医结合急救杂志

ABSTRACT

Objective To explore the influence of Ruineng nutritional fluid on nutrition status, immunity and prognosis in severe patients with mechanical ventilation (MV). Methods Eighty-four patients with severe respiratory failure and MV admitted to Xiaoshan District First People's Hospital from January 2015 to December 2016 were enrolled, and they were divided into an observation group and a control group according to the different methods of treatment, each group 42 cases. The patients in control group were given homogenate meat for enteral nutrition (EN) support, and those in observation group, given Ruineng nutritional fluid. The changes of serum nutrition indexes, T lymphocyte subgroups, disease outcomes, nutrition related complications, etc. indicators were observed before and after treatment in both groups. Results After treatment the levels of serum albumin (ALB), prealbumin (PA), hemoglobin (Hb) were significantly higher than those before treatment in both groups, and the degrees of increase after treatment of observation group were more obvious compared with those in the control group [ALB (g/L) 35.63±4.21 vs. 30.45±3.52, PA (mg/L) 253.12±24.32 vs. 240.23±20.31, Hb (g/L) 145.12±7.32 vs. 131.02±7.05, all P < 0.05]; after treatment, the levels of CD4+, CD8+and CD4+/CD8+were significantly lower than those before treatment in the two groups, but the levels of CD4+and CD4+/CD8+in observation group were significantly higher than those in the control group (CD4+ 0.41±0.03 vs. 0.36±0.02, CD4+/CD8+ 1.46±0.20 vs. 1.30±0.18, both P < 0.05). The time of MV (days 7.82±1.04 vs. 10.13±1.25) and intensive care unit (ICU) hospital stay (days 11.36±1.32 vs. 15.40±1.52) in observation group were significantly shorter than those in the control group, and the incidence of ventilator associated pneumonia [VAP 11.90% (5/42) vs. 33.33% (14/42)], the fatality rate [2.38% (1/42) vs. 7.14% (3/42)] and the incidence of nutrition related complications [19.05% (8/42) vs. 52.38% (22/42)] were significantly lower in observation group than those in the control group. Conclusion Ruineng nutritional fluid can shorten the time of MV and ICU hospital stay, reduce the incidence of EN associated complications, that is possibly related to the improvement of patients' nutritional status and regulation of their immune function.