Clinical effect of Jianpi Xiaotang granule on mechanical ventilated patients with stress hyperglycemia / 中国中西医结合急救杂志

ABSTRACT

Objective To analyze the clinical effects of Jianpi Xiaotang granule on mechanical ventilated (MV) patients with stress hyperglycemia. Methods A total of 88 MV patients with stress hyperglycemia admitted to Department of Critical Care Medicine of Deqing People's Hospital from March 2013 to September 2016 were enrolled, and they were divided into an observation group and a control group according to the random digital table method, each group 44 cases. All the patients were given insulin pump therapy, the observation group additionally received Jianpi Xiaotang granule (constituent astragalus 2 bags, rhizoma dioscorea 1 bag, radix bupleuri 1 bag, radix curcumae 1 bag, ramuli euonymi 1 bag, rhizoma alismatis 1 bag, rhizoma polygonati 2 bags, puerarin 1 bag, coptis chinensis 1 bag, polygonum multiflorum 1 bag, each bag of granule is equivalent to the original medicine 10 g) one dose a day, 1/2 dose twice a day administered with water orally. The differences in clinically related indexes, insulin dosage, insulin treatment period, MV time, and in the incidences of adverse reactions, such as hypoglycemia and infection were compared between the two groups. Results The insulin dosage (U/d 25±6 vs. 42±8), insulin treatment period (days 8±3 vs. 12±5), MV time (days 10±4 vs. 14±6), the incidences of adverse reactions of hypoglycemia [6.8% (3/44) vs. 22.7% (10/44)] and infection [4.5% (2/44) vs. 20.5% (9/44)] in the observation group were significantly lower than those in the control group (all P ＜ 0.05). Conclusion Jianpi Xiaotang granule can reduce the dose of insulin, shorten the periods of insulin treatment and MV, and decrease the risk of incidences of hypoglycemia and infection in MV patients with stress hyperglycemia.