Association of Vitamin B12 Deficiency and Metformin Use in Patients with Type 2 Diabetes
Journal of Korean Medical Science
;
: 965-972, 2014.
Article
in English
| WPRIM
| ID: wpr-70749
ABSTRACT
We evaluated the prevalence of vitamin B12 deficiency and associated factors in type 2 diabetes patients using metformin. A total of 799 type 2 diabetes patients using metformin was enrolled. Vitamin B12 and folate levels were quantified by chemiluminescent enzyme immunoassay. Vitamin B12 deficiency was defined as vitamin B12 4 ng/mL). The prevalence of vitamin B12 deficiency in metformin-treated type 2 diabetes patients was 9.5% (n = 76), and the mean vitamin B12 level was 662.5 +/- 246.7 pg/mL. Vitamin B12 deficient patients had longer duration of metformin use (P or = 2,000 mg were 2.52 (95% CI, 1.27-4.99, P = 0.008) and 3.80 (95% CI, 1.82-7.92, P or = 10 yr were 4.65 (95% CI, 2.36-9.16, P 1,000 mg) and longer durations (> or = 4 yr) of treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Patients
/
Time Factors
/
Vitamin B 12
/
Vitamin B 12 Deficiency
/
Immunoassay
/
Odds Ratio
/
Prevalence
/
ROC Curve
/
Area Under Curve
/
Diabetes Mellitus, Type 2
Type of study:
Etiology study
/
Prevalence study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2014
Type:
Article
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