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Degree of fibrosis of adenomyotic myometrium and its relationship with dysmenorrhea / 中华妇产科杂志
Chinese Journal of Obstetrics and Gynecology ; (12): 689-693, 2018.
Article in Chinese | WPRIM | ID: wpr-707816
ABSTRACT
Objective To investigate degrees of fibrosis of adenomyosis(AM)myometrium and explore its relationship with dysmenorrhea. Methods Thirty AM patients who had hysterectomy from July, 2015 to December, 2016 in Beijing Obstetrics and Gynecology Hospital were selected as AM group; 28 cases of hysterectomy due to cervical lesions(none AM)were selected as control group. The area ratio of collagen fiber in the two groups was analysed by modified Masson stain, and the expression of collagen type Ⅰprotein in the two groups was analysed by immunohistochemical method. Results (1)The degree of fibrosisthe area ratio of collagen fiber and the expression of collagen type Ⅰof AM group [(34.5±5.1)%, 0.23±0.06] were significantly higher than those of control group [(26.7±10.1)%,0.18±0.08; all P<0.05].(2)The relationship between the degree of fibrosis and dysmenorrhea the area ratio of collagen fiber and the expression of collagen type Ⅰ in severe dysmenorrhea, moderate dysmenorrhea, and none-mild dysmenorrhea were(35.3± 4.3)%,0.25±0.05;(35.7±3.2)%, 0.26±0.06;(25.0±2.9)%,0.15±0.03, there were significantly different among them(all P<0.01). And the area ratio of collagen fiber, the expression of collagen type Ⅰ were positively correlated with the degree of dysmenorrhea(r=0.50, 0.50; all P<0.05). Conclusions The area ratio of collagen fiber and the expression of collagen type Ⅰin AM are higher than in control group, and positively correlated with the severity of dysmenorrhea. These results suggest the degrees of fibrosis might be correlated with dysmenorrhea.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Obstetrics and Gynecology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Obstetrics and Gynecology Year: 2018 Type: Article