Perspective of Helicobacter pylori Research: Molecular Pathogenesis of Helicobacter pylori Virulence Factors / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 181-188, 2005.
Article
in Korean
| WPRIM
| ID: wpr-70850
ABSTRACT
Helicobacter pylori (H. pylori) causes chronic gastritis in human stomach, a minority of which progress to peptic ulcer disease, atrophic gastritis, or gastric malignancies. Clinical outcomes of H. pylori infection has been shown to depend on the variability of H. pylori virulence factors, host susceptibility, environmental factors and their interactions. This review provides an update on the molecular pathogenesis of H. pylori infection, focused on H. pylori virulence factors, H. pylori-gastric epithelium interactions, and modulation of host cell signaling. Understanding of H. pylori molecular pathogenic mechanism will facilitate the development of novel treatment strategies for eradication of the bacterium and prevention of H. pylori-induced gastropathy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Helicobacter pylori
/
Helicobacter Infections
/
Virulence Factors
Type of study:
Etiology study
Limits:
Humans
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2005
Type:
Article
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