Human Adenovirus Type 5 as a Delivery Vector is Not Neutralized in Field Serum Samples of Cattle, Pig, and Goat of Republic of Korea
Journal of Bacteriology and Virology
;
: 269-273, 2014.
Article
in English
| WPRIM
| ID: wpr-70868
ABSTRACT
Human adenovirus type 5 (hAd5) vectors have been demonstrated to be useful vehicles for gene expressions in animals. However, it has not been reported whether hAd5 transduction might be hampered in the sera of livestock animals in Republic of Korea. We collected 205 samples of livestock animals, such as pig (n=84), cattle (n=84), and goat (n=37) in Korea. The neutralizing antibody (NAb) titers to hAd5 virus were less than 15 in most of samples. Only 8% of goat samples had a NAb titer of 15 or 30. Thus, we showed that hAd5 virus was not neutralized in sera from cattle, pig, and goat, and suggest that the hAd5 vector could be used for the effective delivery of vaccines or proteins in livestock animals in the field.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Goats
/
Vaccines
/
Gene Expression
/
Adenoviruses, Human
/
Antibodies, Neutralizing
/
Republic of Korea
/
Livestock
/
Korea
Limits:
Animals
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Bacteriology and Virology
Year:
2014
Type:
Article
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