Effect of microRNA-21 on the tumor biological behavior and research progress of molecular imaging and therapy targeting microRNA-21 / 中华核医学与分子影像杂志

ABSTRACT

MicroRNAs (miRNAs) is a set of single-stranded RNA molecules with a length of 18-27 nucleotides,which can regulate the genesis and development of tumor and play the role of tumor suppres sor or oncogenic function by regulating its targeted gene-related signaling pathways.MicroRNA-21 (miR-21)is one of the early discovered miRNAs in human cells,and its expression is significantly elevated in a majority of cancers.The abnormal expression of miR-21 is closely associated with pathogenesis and progression of cancers.In this review,the progress of miR-21 in the occurrence,development,metastasis,treatment and molecular imaging of malignant tumors are summarized.