Imaging analysis of 18 F-FDG PET/ CT in patients with multiple myeloma / 中华核医学与分子影像杂志

ABSTRACT

Objective To analyze the imaging characteristics of 18 F-fluorodeoxyglucose ( FDG) PET/ CT in patients with multiple myeloma (MM). Methods Sixty-eight patients (41 males, 27 females, age (61.5±17.2) years) with pathologically proven MM were retrospectively reviewed between January 2011 and August 2016. Imaging characteristics of 18 F-FDG PET/ CT in patients were analyzed. Maximum stand-ardized uptake value (SUVmax ), score of the bone involvement (bones of whole body were classified into 10 groups, and when 1 group was involved, the score was 1), the number of bone lesions and soft tissue swell-ing around bone lesions were investigated. Results A total of 1310 lesions were detected in 68 MM pa-tients. The SUVmax varied widely and mild metabolic activity (2.5≤SUVmax<5.0) was observed in the high-est proportion of MM patients (49.8％, 652/ 1310). The SUVmax of MM patients was 6.63±3.02. The score of bone involvement was 4.49±3.01. The number of bone lesions was 10.50(3.00, 33.00), and soft tissue swelling around bone lesions was observed in 22 patients. Conclusions There are special imaging charac-teristics of 18 F-FDG PET/ CT in MM patients, such as multiple osteolytic lesions with mild to moderate met-abolic activity, clear boundary and extensive bone involvement, and lesions usually limit to the skeletal sys-tem. The characteristics are of certain value in the diagnosis and differential diagnosis of MM.