Association between serum level of thyroid hormones and severity of coronary artery stenosis in postmenopausal women with UAP / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the association between serum level of thyroid hormones and sever ity of coronary artery stenosis (CAS) in postmenopausal women with unstable angina pectoris (UAP).Methods Two hundred and three postmenopausal women with normal thyroid function were divided into UAP group (n=105) and control group (n=98).The patients in UAP group were further divided into mild-moderate CAS (n=35) and severe CAS (n=70) according to their Gensini score.The association between serum levels of TSH,FT3,FT4 and severity of CAS in UAP group was analyzed.Results The age was older,the history of smoking was longer,the incidence of hypertension,DM,chronic renal disease was higher,the systolic pressure and serum Lp (a) level were higher while that of FT3 and FT4 was lower in UAP group than in control group (P＜0.05).The serum level of TC and LDL-C was higher while that of FT3 was lower in severe CAS than in mild-moderate CAS (P＜0.05).Pearson correlation analysis showed that the serum level of FT3 was negatively associated with that of LDL-C (r=-0.217,P=0.026).Multivariate logistic regression analysis revealed that the low serum level of FT3 was closely associated with the severity of CAS (B=-2.388,OR=0.092,95％CI0.026-0.326,P=0.000).Conclusion The low serum level of FT3 is closely associated with the severity of CAS in postmenopausal women with UAP.