Relationship between serum levels of visfatin,matrix metalloproteinase in acute myocardial infarction patients / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the relationship between serum levels of visfatin,MMP-2 and MMP-9 in AMI patients.Methods Seventy-five AMI patients served as an AMI group and 60 age-and gender-matched subjects undergoing physical examination served as a control group in this study.Their serum levels of visfatin,MMP-2 and MMP-9 were measured and other biochemical parameters were recorded by ELISA.The relationship of serum levels of visfatin with those of MMP-2,MMP-9,hs-CRP and biochemical parameters was analyzed by Pearson correlation analysis.Results The serum levels of LDL-C,visfatin,MMP-2 MMP-9 and hs-CRP were significantly higher in AMI group than in control group (3.45±0.87 mmol/L vs 2.89±0.65 mmol/L,8.06±2.21 μg/L vs 5.53±1.23 μg/L,150.18 ± 74.58 μg/L vs 64.60±25.86 μg/L,478.77±165.46 μg/L vs 263.54±99.35 μg/L,12.07±2.50 mg/L vs 4.62±1.82 mg/L,P＜0.01).The serum levels of visfatin were positively related with those of MMP-2,MMP-9 and hs-CRP.Conclusion The serum visfatin level is significantly higher in AMI patients,indicating that the serum visfatin level is closely related with the rupture of atherosclerotic plaques and can thus be used as an important marker of unstable atherosclerotic plaques and the rupture of atherosclerotic plaques.